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| Title | : | Long Non-Coding RNAs (Progress in Molecular and Subcellular Biology) |
| Author | : | |
| Rating | : | 4.25 (994 Votes) |
| Asin | : | 364216501X |
| Format Type | : | paperback |
| Number of Pages | : | 208 Pages |
| Publish Date | : | 2015-04-02 |
| Language | : | English |
Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. They take part in the recruitment of chromatin modifying complexes and reg
They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dos
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