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Download ^ The Initiation of DNA Replication in Eukaryotes PDF by # Springer eBook or Kindle ePUB Online free. The Initiation of DNA Replication in Eukaryotes Very well researched, organized, and relevant, although challenging for a non-expert in DNA replication. Steven Jon Kaplan This is an excellently written book which contains a lot of very recent material which cannot be found in any other single source. The topics are complex and, not being an expert in this specialized field, it would perhaps have been helpful to have some kind of simplified introduction to some of the information which requires a high degree of understanding of the field in or
| Title | : | The Initiation of DNA Replication in Eukaryotes |
| Author | : | |
| Rating | : | 4.45 (870 Votes) |
| Asin | : | 3319246941 |
| Format Type | : | paperback |
| Number of Pages | : | 563 Pages |
| Publish Date | : | 2013-11-11 |
| Language | : | English |
While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.. Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the
Dr. Dr. In graduate school, Daniel Kaplan worked with Nobel Laureate Thomas Steitz at Yale University to determine how the bacterial replication fork helicase, DnaB, modulates DNA structure. Kaplan attended Yale Medical School and received training in cancer research before entering graduate school. Kaplan led a team that published primary research articles that investigated how DNA replication is initiated in budding yeast. Kaplan is also the Assistant Course Director for the Medical Microbiology course. As a post-doctoral fellow, Daniel Kaplan worked with National Academy of Science member Mike
Very well researched, organized, and relevant, although challenging for a non-expert in DNA replication. Steven Jon Kaplan This is an excellently written book which contains a lot of very recent material which cannot be found in any other single source. The topics are complex and, not being an expert in this specialized field, it would perhaps have been helpful to have some kind of simplified introduction to some of the information which requires a high degree of understanding of the field in order to fully
Dr. Kaplan is also the Assistant Course Director for the Medical Microbiology course. . As an assistant professor at Vanderbilt University, Dr. Kaplan led a team that published primary research articles that investigated how DNA replication is initiated in budding yeast. Daniel Kaplan has been studying microbiology, biochemistry, and genetics for over 20 years. As a post-doctoral fellow, Daniel Kaplan worked with National Academy of Science member Mike O’Donnell at Rockefeller Unive
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